Duloxetine pharmacology

Discussion in 'Rx Price Comparison' started by DoTJ, 30-Aug-2019.

  1. Duloxetine pharmacology


    Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. The United States Department of Justice fined Glaxo Smith Kline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression. Paroxetine is primarily used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder, generalized anxiety disorder, premenstrual dysphoric disorder and menopausal hot flashes. A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression. Food and Drug Administration approved low-dose paroxetine for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause. They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent or inferior to other antidepressants. Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%), and sexual dysfunction (≥10% incidence). After consolidation of the antidepressive response, it is recommended to continue treatment for several months, in order to avoid relapse. Therapeutic response is usually seen after 2-4 weeks of treatment. However, there is no clinical evidence suggesting that patients not responding to the initial recommended dose may benefit from dose up-titrations. Dosages above 60 mg once daily, up to a maximum dose of 120 mg per day have been evaluated from a safety perspective in clinical trials. Major Depressive Disorder: The starting and recommended maintenance dose is 60 mg once daily with or without food. In patients responding to duloxetine, and with a history of repeated episodes of major depression, further long-term treatment at a dose of 60 to 120 mg/day could be considered. Generalised Anxiety Disorder: The recommended starting dose in patients with generalised anxiety disorder is 30 mg once daily with or without food.

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    Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor SSRI class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. Duloxetine is not recommended for use in children less than 7 years of age; safety and efficacy have not been established. Duloxetine is FDA-approved for use in children and adolescents 7 years and older with generalized anxiety disorder GAD; efficacy for major depressive disorder MDD was not established in two 10-week controlled trials with 800 pediatric patients 7 years and older. Mechanism of action, side effects, contraindications and dosage of urological drugs, from the online textbook of urology by D. Manski

    ; Eli Lilly and Co.) is classified as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It was approved by the Food and Drug Administration (FDA) in August 2004 for the treatment of major depressive disorder (MDD) and one month later received an indication for the treatment of peripheral neuropathic pain associated with diabetic neuropathy (DN). MDD is characterized by a depressed mood or loss of interest in activities for a minimum of 2 weeks. At least four other symptoms must be experienced by the patient and may include fatigue, change in sleep patterns or appetite, impaired concentration, feelings of guilt, or periodic thoughts of death or suicide. MDD may manifest as unipolar depression, referring only to the periodic occurrence of depressive symptoms, or as bipolar depression, where depressive symptoms alternate with manic episodes consisting of a combination of increased psychomotor activity, decreased need for sleep, and delusional, grandiose, paranoid, or psychotic behavior. A possible cause of depression is a medical illness, either through psychological stress, the disease itself, or the pharmacological treatment. Neuroendocrine hormonal variations can also contribute to the etiology of MDD, especially when combined with environmental stressors (e.g., death of a relative, assault, or severe relationship issues). Unfortunately, many sections of the German textbook are not translated yet. As a workaround, you can use the Google Translator function for this website (original German link: Medikamente).

    Duloxetine pharmacology

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  7. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor SSNRI antidepressant.

    • Duloxetine Ligand page IUPHAR/BPS Guide to PHARMACOLOGY.
    • Pharmacology of Urological Drugs –.
    • Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6..

    Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is taken by mouth. Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Severe side effects include an increased risk of suicide. Duloxetine + Mecobalamin is a generic medicine name and there are several brands available for it. Some of the brands for duloxetine + mecobalamin might be better known than duloxetine + mecobalamin itself. Duloxetine Cymbalta, Yentreve a serotonin-norepinephrine reuptake inhibitor for major depression. Australian prescriber review. The onset of efficacy was defined as a 20% sustained reduction in the patient’s score on the Hamilton Rating Scale for Depression Maier subscale, by the second week of treatment.

     
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