Tamoxifen duration

Discussion in 'Approved Canadian Pharmacies Online' started by KMY 2, 18-Aug-2019.

  1. lango Moderator

    Tamoxifen duration


    Tamoxifen is a hormonal therapy drug used to treat breast cancer, womb cancer and sometimes other cancers and conditions. It is best to read this information with our general information about hormonal therapies and the type of cancer you have. Like all cancer drugs, tamoxifen can cause side effects. Your cancer doctor, nurse, or pharmacist will tell you how often you will have it. Some of the side effects can be serious, so it is important to read the detailed information below. Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you feel unwell or have severe side effects, including any we do not mention here. Your cancer doctor or nurse can explain the risk of these side effects to you. If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment. Tamoxifen can be given alone or with other types of treatment. For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published in on December 5, 2012—are likely to change clinical practice, several researchers said. Nearly 7,000 women with early-stage, estrogen receptor-positive breast cancer were enrolled in the trial between 19. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. This finding is consistent with those from other trials of adjuvant tamoxifen therapy, which showed that 5 years of tamoxifen can substantially reduce the risk of the cancer returning and of cancer death in the next few years, what one of the trial investigators, Richard Gray, MSc, of Oxford University, UK, called a "carryover effect." The improved outcomes with longer tamoxifen use emerged only after the 10-year mark, Gray explained during an SABCS press briefing. Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower.

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    Tamoxifen Nolvadex hormone therapy side effects, how it's given, how it. Tamoxifen should be taken at about the same time each day with a full glass of. Taking adjuvant tamoxifen for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the FDA to treat people.

    It is usually given as an additional treatment following surgery, to reduce the risk of breast cancer returning in the same breast or a new breast cancer developing in either breast, or spreading somewhere else in the body. If you’re going to take tamoxifen as part of your treatment for primary breast cancer, your specialist will tell you when it’s best to start. Tamoxifen can be used to treat primary breast cancer. It may also be used to reduce the risk of breast cancer developing in women who have a significant family history of breast cancer. Back to top Tamoxifen may be prescribed if you have primary breast cancer, recurrence or secondary breast cancer. Find out more about how male breast cancer is treated. Most breast cancers in men are oestrogen receptor positive. If your cancer is found to be hormone receptor negative, then tamoxifen will not be of any benefit to you. Researchers find that women with postmenopausal hormone receptor (HR)-positive breast cancer may undergo shorter treatments of Arimidex, which may in turn cause less bone fractures. Investigators with the Austria Breast and Colorectal Cancer Study Group announced today that years can safely be shaved off Arimidex (anastrozole) treatment without affecting disease-free survival (DFS) for women with postmenopausal hormone receptor (HR)-positive breast cancer. Additionally, shorter treatment spans can significantly reduce bone fractures, a side effect of aromatase-inhibitor (AI) therapy. Results from the ABCSG-16 phase III trial were presented at the 2017 San Antonio Breast Cancer Symposium held in San Antonio, Texas. For years, oncologists have followed up initial AI therapy with extended therapy for up to five years. D., director and chairman, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, recommended that oncologists immediately incorporate the new findings into practice by significantly reducing the use of adjuvant AI therapy following initial treatment. “There is simply no rationale to keep most patients on extended AI for longer than two years,” said Gnant, the study’s lead author. Investigators enrolled 3,484 postmenopausal women with HR-positive early-stage breast cancer from February 2004 to June 2010.

    Tamoxifen duration

    Duration of adjuvant tamoxifen therapy. - NCBI, Ten Years of Tamoxifen Reduces Breast Cancer Recurrences.

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  5. Two randomised trials have compared 5 years versus 10 years of tamoxifen therapy following surgery for hormone receptor-positive early breast cancer.

    • Breast cancer and duration of tamoxifen..
    • Tamoxifen Uses, Side Effects, and More -.
    • Tamoxifen citrate - GLOWM.

    For how long should adjuvant treatment with tamoxifen be continued? Controversy remains. Recent reports from. In the aTTom study, women continuing tamoxifen for 10 years had a 25%. an AI for up to 5 years, for a total duration of treatment of 7-8 years Years of tamoxifen reduces risk of breast cancer recurrence and breast cancer–related mortality in patients with ER-positive disease as compared with 5.

     
  6. Lonely Dragon Moderator

    Clomiphene citrate, marketed in pill form as Clomid or Serophene, has long been used for female infertility to spur the ovaries to produce mature eggs. It works by stimulating a part of the brain (the pituitary gland) that controls production of two hormones key to reproductive health: follicle stimulating hormone (FSH) and luteinizing hormone (LH). FSH stimulates sperm production in the testicles, and LH stimulates testosterone production. So it made sense to a number of urologists who treat male infertility to try clomiphene citrate in men. Indeed, judicious use of clomiphene citrate can stimulate sperm production and sperm quality in men with reduced testicular function. A number of studies have now conclusively demonstrated that this strategy works—and it does so by working with the body rather than dumping extra testosterone on it from outside. In a recent case study, a group of men with below-normal levels of testosterone were studied. Their average testosterone level at the start of the study was about 250 nanograms per deciliter. The men were randomly assigned to get either clomiphene or a placebo (dummy pill). After two months, the testosterone levels in the clomiphene group had more than doubled while the levels in the placebo group had risen only modestly and were not statistically significant. Clomid for Men! Side Effects & Risks! Why Men Must Use Clomid Off label therapies for testosterone replacement - NCBI - NIH
     
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